Vision
Innovative Biotechnology Solutions Through Cell-Specific Targeting
Mission
To Implement Clinical Research and Targeted Therapies for Pandemic Infectious Diseases, Cancers, and Autoimmune Disorders
Cancer Studies
Let There Be Hope Medical Research Institute is sponsoring an important new anti-cancer study PAWS for PEOPLE to develop a new immune treatment for companion animals and cancer patients with malignancies that have failed conventional therapies as a consequence of tumor resistance.
Our study, to begin in 2010, will be conducted under the direction, supervision, and management of the Comparative Oncology Project, a division of the National Cancer Institute. The initial investigation will be conducted at a number of Veterinary Medical centers collaborating with the NCI, where our experimental treatment protocol will be administered to pet dogs suffering from malignant Lymphoma. Additional canine malignancies will be studied in follow up stages with the NCI. The principle objective of this initial Lymphoma study will be to determine treatment response to this novel immune therapy in pet dogs, saving their lives, and subsequently to apply to the FDA for rapid Orphan Drug approval for humans with a variety of carcinomas that have failed treatments.
The immune-modulator compound has been extensively studied and biologically characterized and has already been shown to significantly eradicate resistant cancers in experimental small animal cancer models. It also has been shown to effectively reprogram human immune cells in laboratory studies from patients with resistant human cancers of the breast, lung, colon, prostate, ovaries and testes.
Its anti-cancer activity results from rallying the body’s immune cells to identify and destroy malignant cells in the primary tumor as well as in the distant metastases.
The first step required for the development of this compound for humans is the treatment of pet dogs suffering from resistant cancers.
The NCI is responsible for development of the treatment protocol with Let There Be Hope, as the Sponsor of this project. The NCI develops the budget, monitors the study and analyzes the data.
Let There Be Hope is responsible for all study costs associated with this project, and must raise charitable funds in tax-deductible donations so that we may complete the first canine project in 2010 and apply for the first human trials by 2012.
Please click here to make a tax-deductible contribution for this important cancer project.
RECENT POSTERS
For a closer look at the science behind our targeting technology, please download recent presentations.
 |
 |
click images to download each poster |
|
INSTITUTIONAL and CORPORATE COLLABORATIONS
Targeting of HIV and Hepatitis C reservoirs:
Rodos BioTarget, GmbH, Hannover, Germany; The Max Planck Institute, Goettingen, Germany; German Primate Center, Goettingen, Germany; U. of Hannover, U. of Essen, U. of Freiburg.
Treatment response in Atopic Diseases:
(Confidential licensed study with anticipated completion 2009).
SIGNATURE PUBLICATIONS
(all research papers, posters, and oral presentations). Click here for PDF download.